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Article

Value and limitations of targeted next-generation sequencing in idiopathic hypereosinophilia: an integrative diagnostic tool in challenging cases.

Clinical and experimental medicine - 23 Jul 2024

Cattaneo Daniele, Marchetti Alfredo, Bucelli Cristina, Galli Nicole, Lionetti Marta, Bellani Valentina, Gianelli Umberto, Passamonti Francesco, Bolli Niccolò, Iurlo Alessandra

Abstract excerpt

Here, we reviewed clinical-morphological data and investigated mutational profiles by NGS in a single-center series of 28 consecutive patients admitted to our hospital between September 2011 and November 2021 for idiopathic hypereosinophilia (HE).Bone marrow (BM) morphology was evaluated in 22 patients: while in six subjects BM was unremarkable, in the remaining cases an increase in BM eosinophils was observed,...

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Identifiers

PMID: 39042228
DOI: 10.1007/s10238-024-01441-w
PMCID: PMC11266199

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