Article
Involvement of the JAK-STAT pathway in the molecular landscape of tyrosine kinase fusion-negative hypereosinophilic syndromes: A nationwide CEREO study.
American journal of hematology - 1 Jun 2024
Groh Matthieu, Fenwarth Laurène, Labro Mathilde, Boudry Augustin, Fournier Elise, Wemeau Mathieu, Marceau-Renaut Alice, Daltro de Oliveira Rafael, Abraham Julie, Barry Marly, Blanche Philippe, Bodard Quentin, Braun Thorsten, Chebrek Safia, Decamp Matthieu, Durel Cécile-Audrey, Forcade Edouard, Gerfaud-Valentin Mathieu, Golfier Camille, Gourguechon Clément, Grardel Nathalie, Kosmider Olivier, Martis Nihal, Melboucy Belkhir Sarah, Merabet Fatiha, Michon Adrien, Moreau Stéphane, Morice Cécile, Néel Antoine, Nicolini Franck E, Pascal Laurent, Pasquier Florence, Pieragostini Andrea, Roche-Lestienne Catherine, Rousselot Philippe, Terriou Louis, Thiebaut-Bertrand Anne, Viallard Jean-François, Preudhomme Claude, Kahn Jean-Emmanuel, Lefevre Guillaume, Duployez Nicolas
Abstract excerpt
We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p < .001). Thirty-five...
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