Article
Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort.
American journal of hematology - 1 Feb 2024
Gurnari Carmelo, Pascale Maria Rosaria, Vitale Antonio, Diral Elisa, Tomelleri Alessandro, Galossi Elisa, Falconi Giulia, Bruno Alessandro, Crisafulli Francesca, Frassi Micol, Cattaneo Chiara, Bertoli Diego, Bernardi Massimo, Condorelli Annalisa, Morsia Erika, Poloni Antonella, Crisà Elena, Caravelli Daniela, Triggianese Paola, Brussino Luisa, Battipaglia Giorgia, Bindoli Sara, Sfriso Paolo, Caroni Federico, Dragani Matteo, Mallegni Flavia, Pilo Federica, Firinu Davide, Curti Antonio, Papayannidis Cristina, Olivieri Attilio, Kordasti Sharham, Albano Francesco, Pane Fabrizio, Musto Pellegrino, Bocchia Monica, Lugli Elisabetta, Breccia Massimo, Frigeni Marco, Dagna Lorenzo, Greco Raffaella, Franceschini Franco, Campochiaro Corrado, Cantarini Luca, Voso Maria Teresa
Abstract excerpt
VEXAS is a prototypic hemato-inflammatory disease combining rheumatologic and hematologic disorders in a molecularly defined nosological entity. In this nationwide study, we aimed at screenshotting the current diagnostic capabilities and clinical-genomic features of VEXAS, and tracked UBA1 longitudinal clonal dynamics upon different therapeutics, including allogeneic hematopoietic cell transplant. We leveraged a...
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