Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified.

doi:10.1038/modpathol.2016.75

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2016

Wang Sa A, Tam Wayne, Tsai Albert G, Arber Daniel A, Hasserjian Robert P, Geyer Julia T, George Tracy I, Czuchlewski David R, Foucar Kathryn, Rogers Heesun J, Hsi Eric D, Bryan Rea B, Bagg Adam, Dal Cin Paola, Zhao Chong, Kelley Todd W, Verstovsek Srdan, Bueso-Ramos Carlos, Orazi Attilio

Abstract excerpt

The distinction between chronic eosinophilic leukemia, not otherwise specified and idiopathic hypereosinophilic syndrome largely relies on clonality assessment. Prior to the advent of next-generation sequencing, clonality was usually determined by cytogenetic analysis. We applied targeted next-generation sequencing panels designed for myeloid neoplasms to bone marrow specimens from a cohort of idiopathic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Examination

Share to Diagnosis, Differential

Share to Hypereosinophilic Syndrome

Share to In Situ Hybridization, Fluorescence

Share to Kaplan-Meier Estimate

Share to Karyotype

Share to Leukemia

Source

Open in PubMed

Identifiers

PMID: 27174585
DOI: 10.1038/modpathol.2016.75

Genes

ASXL1
CBL
NOTCH1
SETBP1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified.PMID 27174585Read ↗

Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.Semantic proximity Read ↗

Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome.Semantic proximity Read ↗

Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome.Semantic proximity Read ↗

The Diagnostic Work-Up of Hypereosinophilia.Semantic proximity Read ↗

Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update.Semantic proximity Read ↗

Molecular Classification and Pathogenesis of Eosinophilic Disorders: 2005 UpdateSemantic proximity Read ↗

Value and limitations of targeted next-generation sequencing in idiopathic hypereosinophilia: an integrative diagnostic tool in challenging cases.Semantic proximity Read ↗

World Health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management.Semantic proximity Read ↗

Eosinophilia/Hypereosinophilia in the Setting of Reactive and Idiopathic Causes, Well-Defined Myeloid or Lymphoid Leukemias, or Germline Disorders.Semantic proximity Read ↗

Chronic Eosinophilic Leukaemia Associated with JAK2 Exon 13 Insertion/Deletion Mutations.Semantic proximity Read ↗

Contemporary Classification and Diagnostic Evaluation of Hypereosinophilia.Semantic proximity Read ↗

Lymphocytic Variant Hypereosinophilic Syndrome: Case Series From a Tertiary Referral Center in CanadaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.