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Article

Q48K mutation in the type IB nitroreductase NrmA is responsible for nitrofurantoin resistance in Enterococcus faecium.

International journal of antimicrobial agents - 1 Sept 2024

Li Pei, Xu Qingqing, Ding Li, Zhang Xuefei, Li Dan, Wang Leilei, Xu Xiaogang, Lin Dongfang, Wang Minggui

Abstract excerpt

OBJECTIVES: Nitrofurantoin is recommended as first-line therapy for the optimal treatment of uncomplicated urinary tract infections (UTIs) caused by enterococci and Escherichia coli. However, the mechanisms of nitrofurantoin resistance in enterococci have not been elucidated. This study aimed to investigate the mechanisms of nitrofurantoin resistance in E. faecium, focusing on the role of the nitroreductase NrmA....

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Anti-Bacterial Agents
Drug Resistance, Bacterial
Enterococcus faecium
Escherichia coli Proteins
Gram-Positive Bacterial Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Nitroreductases

Urinary Tract Infections

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PMID: 39032672
DOI: 10.1016/j.ijantimicag.2024.107277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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