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Improving nitrofurantoin resistance prediction in Escherichia coli from whole-genome sequence by integrating NfsA/B enzyme assays.

Antimicrobial agents and chemotherapy - 9 Jul 2024

Dulyayangkul Punyawee, Sealey Jordan E, Lee Winnie W Y, Satapoomin Naphat, Reding Carlos, Heesom Kate J, Williams Philip B, Avison Matthew B

Abstract excerpt

Nitrofurantoin resistance in Escherichia coli is primarily caused by mutations damaging two enzymes, NfsA and NfsB. Studies based on small isolate collections with defined nitrofurantoin MICs have found significant random genetic drift in nfsA and nfsB, making it extremely difficult to predict nitrofurantoin resistance from whole-genome sequence (WGS) where both genes are not obviously disrupted by nonsense or...

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Identifiers

PMID: 38767379
DOI: 10.1128/aac.00242-24
PMCID: PMC11232377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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