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Article

A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity.

Journal of bacteriology - 1 May 2009

Tavares Ana Filipa N, Nobre Lígia S, Melo Ana M P, Saraiva Lígia M

Abstract excerpt

In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that...

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Aldehyde Oxidoreductases
Mutation
Nitroreductases
Oligonucleotide Array Sequence Analysis
Phylogeny

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Staphylococcus aureus

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PMID: 19286809
DOI: 10.1128/JB.00022-09
PMCID: PMC2687171

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