Article

BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes

2023-08-10

Abstract excerpt

Integrator is a multi-subunits protein complex involved in regulation of gene expression. Several Integrator subunits have been found to be mutated in human neurodevelopmental disorders, suggesting a key role for the complex in the development of nervous system. BRAT1 is similarly linked with neurodegenerative diseases and neurodevelopmental disorders such as rigidity and multifocal-seizure syndrome. Here, we sho...

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Literature Corpus work: 83538568-97a2-54aa-976b-98ba121f7a57
DOI: 10.1101/2023.08.10.552743

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