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Association analysis of miRNA-146a and miRNA-196a polymorphism with breast cancer risk in Khyber Pakhtunkhwa, Pakistan: a preliminary study.

Molecular biology reports - 20 Jul 2024

Hina Gul I, Khan Najeeb Ullah, Muntaha Sidra Tul, Ullah Asad, Khan Sherhayat, Alanzi Abdullah R, Ali Ijaz, Chen Tianhui

Abstract excerpt

BACKGROUND: microRNAs (miRNAs) are small, noncoding RNA molecules, functioning either as oncogenes or tumor suppressor genes. SNPs in miRNAs might modify the expression of genes associated with miRNAs, enhancing susceptibility to breast cancer. Both miRNA-146a (rs2910164) and miRNA-196a (rs11614913) are identified and significantly associated with breast cancer risk in several ethnicities, but remains unexplored...

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PMID: 39031244
DOI: 10.1007/s11033-024-09765-2

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