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A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates

13 Jun 2024

Abstract excerpt

The emergence of SARS-CoV-2 variants raises concerns about the efficacy of existing COVID-19 vaccines and therapeutics. Previously, we identified a conserved cryptic class 5 epitope of SARS-CoV-2 receptor binding domain (RBD) by two cross-neutralizing antibodies 7D6 and 6D6. Intriguingly, this site remains resistant to substantial mutations occurred in ever-changing SARS-CoV-2 subvariants. As compared to class 3...

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PMID: 39015149
DOI: 10.1016/j.isci.2024.110208

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