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Article

Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines.

Scientific reports - 15 Jul 2024

De Greef Julien, Akue Mathilde, Panin Nadtha, Delongie Kévin-Alexandre, André Marina, Mahieu Gwenaëlle, Hoste Emilia, Elens Laure, Belkhir Leïla, Haufroid Vincent

Abstract excerpt

Bictegravir, a key second-generation integrase strand transfer inhibitor in the treatment of HIV, is subject to active efflux transport mediated by ABCB1 (P-glycoprotein). Several coding variants of ABCB1 have been described and associated with variable effects on substrate drugs pharmacokinetics. Here, we investigated the effect of the four most common coding ABCB1 single nucleotide polymorphisms (i.e.,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39009738
DOI: 10.1038/s41598-024-66809-0
PMCID: PMC11251168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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