G-quadruplex structures in FGFR3 promoter negatively regulate its gene expression and DNA replication.

doi:10.1016/j.bbrc.2024.150384

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Article

G-quadruplex structures in FGFR3 promoter negatively regulate its gene expression and DNA replication.

Biochemical and biophysical research communications - 20 Oct 2024

Shi Ke, Chen Kuida, Lu Shipeng, Luo Qiong, Xu Qiang

Abstract excerpt

FGFR3 activating mutations and abnormal expression are linked to tumor development. However, the current state of research on FGFR3 gene expression regulation is relatively insufficient. In this study, we have reported that the FGFR3 promoter's positive strand contains several G-tracts and most likely forms a G-quadruplex (G4) structure. Circular dichroism investigations revealed that oligonucleotides from this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39003866
DOI: 10.1016/j.bbrc.2024.150384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.