Article
Mutational and expressional analysis of RFC3, a clamp loader in DNA replication, in gastric and colorectal cancers.
Human pathology - 1 Oct 2010
Kim Yoo Ri, Song Sang Yong, Kim Sung Soo, An Chang Hyeok, Lee Sug Hyung, Yoo Nam Jin
Abstract excerpt
Parts of gastric (GC) and colorectal cancers (CRC) exhibit microsatellite instability (MSI) that causes frameshift mutations and contributes to cancer development. DNA replication and repair play crucial roles in maintenance of genome stability, and their alterations contribute to cancer development. In this study, we analyzed mutation of RFC1 and RFC3, clamp loaders in DNA replication, in GC and CRC with MSI. We...
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