Article
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nature reviews. Neuroscience - 1 Oct 2008
Bertram Lars, Tanzi Rudolph E
Abstract excerpt
The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2)), and one genetic risk factor for late-onset AD (the gene that encodes apolipoprotein E (APOE)). A large number of studies that aimed to help uncover the remaining...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apolipoproteins E
- Brain Chemistry
- Genetic Predisposition to Disease
- Humans
- Meta-Analysis as Topic
- Mutation
- Presenilins
- Risk Factors