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Article

Identification of mechanisms modulating chlorhexidine and octenidine susceptibility in Proteus mirabilis.

Journal of applied microbiology - 2 Jul 2024

Pelling Harriet, Bennett Vicky, Bock Lucy J, Wand Matthew E, Denham Emma L, MacFarlane Wendy M, Sutton J Mark, Jones Brian V

Abstract excerpt

AIMS: We aimed to identify mechanisms underlying the tolerance of Proteus mirabilis-a common cause of catheter associated urinary tract infection-to the clinically used biocides chlorhexidine (CHD) and octenidine (OCT). METHODS AND RESULTS: We adapted three clinical isolates to grow at concentrations of 512 µg ml-1 CHD and 128 µg ml-1 OCT. Genetic characterization and complementation studies revealed mutations...

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Source

Identifiers

PMID: 38991984
DOI: 10.1093/jambio/lxae173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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