Article
Detection of allele-specific expression in spatial transcriptomics with spASE.
Genome biology - 8 Jul 2024
Zou Luli S, Cable Dylan M, Barrera-Lopez Irving A, Zhao Tongtong, Murray Evan, Aryee Martin J, Chen Fei, Irizarry Rafael A
Abstract excerpt
Spatial transcriptomics technologies permit the study of the spatial distribution of RNA at near-single-cell resolution genome-wide. However, the feasibility of studying spatial allele-specific expression (ASE) from these data remains uncharacterized. Here, we introduce spASE, a computational framework for detecting and estimating spatial ASE. To tackle the challenges presented by cell type mixtures and a low...
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