Article

Cell type-specific inference of differential expression in spatial transcriptomics

2021-12-26

Abstract excerpt

Spatial transcriptomics enables spatially resolved gene expression measurements at near single-cell resolution. There is a pressing need for computational tools to enable the detection of genes that are differentially expressed (DE) within specific cell types across tissue context. We show that current approaches cannot learn cell type-specific DE due to changes in cell type composition across space and the fact t...

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Literature Corpus work: 0ed3a05f-cbd0-5445-aa2b-3752d2117278
DOI: 10.1101/2021.12.26.474183

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