Article
Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.
Annals of neurology - 1 Apr 1996
Dürr A, Stevanin G, Cancel G, Duyckaerts C, Abbas N, Didierjean O, Chneiweiss H, Benomar A, Lyon-Caen O, Julien J, Serdaru M, Penet C, Agid Y, Brice A
Abstract excerpt
Patients with spinocerebellar ataxia 3 (SCA3) and Machado-Joseph disease (MJD) carry an expanded CAG repeat in the MJD1 gene. One hundred twenty families of different geographic origin with autosomal dominant cerebellar ataxia (ADCA) type I were tested. Thirty-four families (126 patients) carried...
Topics
- Adult
- Age of Onset
- Central Nervous System
- Female
- Gene Frequency
- Humans
- Machado-Joseph Disease
- Male
- Middle Aged
- Mutation
- Repetitive Sequences, Nucleic Acid
- Spinocerebellar Degenerations