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Article

The metabolic consequences of 'yo-yo' dieting are markedly influenced by genetic diversity.

International journal of obesity (2005) - 1 Aug 2024

Thillainadesan Senthil, Lambert Aaron, Cooke Kristen C, Stöckli Jacqueline, Yau Belinda, Masson Stewart W C, Howell Anna, Potter Meg, Fuller Oliver K, Jiang Yi Lin, Kebede Melkam A, Morahan Grant, James David E, Madsen Søren, Hocking Samantha L

Abstract excerpt

BACKGROUND: Weight loss can improve the metabolic complications of obesity. However, it is unclear whether insulin resistance persists despite weight loss and whether any protective benefits are preserved following weight regain (weight cycling). The impact of genetic background on weight cycling is undocumented. We aimed to investigate the effects of weight loss and weight cycling on metabolic outcomes and...

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Identifiers

PMID: 38961153
DOI: 10.1038/s41366-024-01542-2
PMCID: PMC11281900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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