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Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning

2 Jul 2024

Abstract excerpt

The classification of B cell lymphomas-mainly based on light microscopy evaluation by a pathologist-requires many years of training. Since the B cell receptor (BCR) of the lymphoma clonotype and the microenvironmental immune architecture are important features discriminating different lymphoma subsets, we asked whether BCR repertoire next-generation sequencing (NGS) of lymphoma-infiltrated tissues in conjunction...

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PMID: 38954728
DOI: 10.1371/journal.pcbi.1011570

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