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Article

Trans vs. cis: a computational study of enasidenib resistance due to IDH2 mutations.

Physical chemistry chemical physics : PCCP - 10 Jul 2024

Lindahl Erik, Arvidsson Erik, Friedman Ran

Abstract excerpt

Isocitrate dehydrogenase 2 (IDH2) is a homodimeric enzyme that plays an important role in energy production. A mutation R140Q in one monomer makes the enzyme tumourigenic. Enasidenib is an effective inhibitor of IDH2/R140Q. A secondary mutation Q316E leads to enasidenib resistance. This mutation was hitherto only found in trans, i.e. where one monomer has the R140Q mutation and the other carries the Q316E...

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Identifiers

PMID: 38953374
DOI: 10.1039/d4cp01571a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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