Article
Clinicopathological differences between T-lymphoblastic leukemia/lymphoma, early T-precursor lymphoblastic leukemia/lymphoma, and mixed-phenotype acute leukemia with T lineage: An analysis of 41 adult cases.
Human pathology - 1 Aug 2024
Takahashi Yuka, Kaimi Yuto, Taniguchi Hirokazu, Ochi Tetsuro, Makino Haruhi, Makita Shinichi, Iwaki Noriko, Fukuhara Suguru, Munakata Wataru, Izutsu Koji, Maeshima Akiko Miyagi
Abstract excerpt
The histopathological diagnosis of T-lymphoblastic leukemia/lymphoma, NOS (T-ALL), is based on morphology and positivity for CD3 and TdT. Early T-precursor lymphoblastic leukemia/lymphoma (ETP-ALL) and mixed-phenotype acute leukemia (MPAL), T/M, and/or B rarely occur and are usually diagnosed using flow cytometry. Using only formalin-fixed paraffin-embedded tissue raises the risk of misdiagnosis due to...
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