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Genetically Predicted Higher Levels of Caffeic Acid Are Protective Against Ulcerative Colitis: A Comprehensive Metabolome Analysis.

Inflammatory bowel diseases - 5 Dec 2024

Naito Takeo, Osaka Ryuya, Kakuta Yoichi, Kawai Yosuke, Khor Seik-Soon, Umeno Junji, Tokunaga Katsushi, Nagai Hiroshi, Shimoyama Yusuke, Moroi Rintaro, Shiga Hisashi, Nagasaki Masao, Kinouchi Yoshitaka, Masamune Atsushi

Abstract excerpt

BACKGROUND: It is crucial to pinpoint the metabolites that cause Crohn's disease (CD) and ulcerative colitis (UC) to comprehend their pathogenesis and identify possible targets for therapy. To achieve this goal, we performed the first metabolome-wide Mendelian randomization (MR) study of Japanese patients with CD and UC. METHODS: As exposure datasets, genetic instruments with blood-circulating metabolites were...

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PMID: 38944808
DOI: 10.1093/ibd/izae143

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