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Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis

28 Jun 2024

Abstract excerpt

BACKGROUND: Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained elusive. METHODS: A siRNA screen in EV-A71 infected-motor neurons was performed targeting 112 genes involved in intracellular membrane trafficking, followed by validation of the top four hits using...

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PMID: 38943128
DOI: 10.1186/s12929-024-01053-2

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