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Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer

28 Jun 2024

Abstract excerpt

Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly invasive tumors that cause loco-regional relapses after initial therapeutic intervention and metastatic outgrowth. The molecular pathways governing the detrimental invasive growth modes in HNSCC remain however understudied. Here, we have established HNSCC patient...

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PMID: 38942893
DOI: 10.1038/s41388-024-03091-4

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