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A genome scale transcriptional regulatory model of the human placenta

28 Jun 2024

Abstract excerpt

Gene regulation is essential to placental function and fetal development. We built a genome-scale transcriptional regulatory network (TRN) of the human placenta using digital genomic footprinting and transcriptomic data. We integrated 475 transcriptomes and 12 DNase hypersensitivity datasets from placental samples to globally and quantitatively map transcription factor (TF)–target gene interactions. In an...

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Share to Epigenetics and DNA Methylation
Share to Pregnancy and preeclampsia studies
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PMID: 38941464
DOI: 10.1126/sciadv.adf3411

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