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Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

2 Dec 2020

Abstract excerpt

While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in human cell types relevant to pregnancy and PTB. We generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and...

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PMID: 33268355
DOI: 10.1126/sciadv.abc8696

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