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Article

HLA-DQA1∗05 Genotype and Immunogenicity to Tumor Necrosis Factor-α Antagonists: A Systematic Review and Meta-analysis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Nov 2023

Solitano Virginia, Facciorusso Antonio, McGovern Dermot P B, Nguyen Tran, Colman Ruben J, Zou Lily, Boland Brigid S, Syversen Silje W, Jørgensen Kristin Kaasen, Ma Christopher, Armuzzi Alessandro, Wilson Aze, Jairath Vipul, Singh Siddharth

Abstract excerpt

BACKGROUND & AIMS: Identifying patients at high risk of immunogenicity is important when selecting tumor necrosis factor (TNF)-α antagonists in patients with immune-mediated inflammatory diseases (IMIDs). We evaluated the association HLA-DQA1∗05 genotype and risk of immunogenicity with TNF-α antagonists. METHODS: Through a systematic review through July 14, 2022, we identified studies in patients with IMIDs...

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PMID: 37061107
DOI: 10.1016/j.cgh.2023.03.044

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