Article
High performance of multiplex fluorescence in situ hybridization to simultaneous detection of BCL2 and BCL6 rearrangements: useful application in the characterization of DLBCLs.
Virchows Archiv : an international journal of pathology - 1 Sept 2021
Marino Federica Zito, Aquino Gabriella, Brunelli Matteo, Scognamiglio Giosuè, Pedron Serena, Ronchi Andrea, Cozzolino Immacolata, Sparano Lucianna, Botti Gerardo, Panico Luigi, De Chiara Anna, Franco Renato
Abstract excerpt
Chromosomal rearrangements involving BCL2, BCL6 and MYC are commonly found in the most frequent B cell lymphomas, namely follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs). Particularly, BCL2-rearrangement represents a diagnostic hallmark in FLs, whereas MYC translocation can occur simultaneously with BCL2 and/or BCL6 rearrangements, defining a specific category of DLBCLs with a poorer...
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