Article
Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients.
Genes - 3 Jun 2024
Ferrari Marco, Vecchio Domizia, D'Alfonso Sandra, Gemma Alessandra, Marino Franca, Comi Cristoforo, Cosentino Marco
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a common chronic autoimmune disease of the central nervous system. In MS, disability progresses unpredictably. Dopamine (DA) is a modulator of immune functions, and compelling evidence supports its involvement in both pathogenesis and treatment of MS. Although single nucleotide polymorphisms (SNPs) in dopaminergic receptor (DR) genes have been extensively studied, their role...
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