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Article

Production of transgenic rabbits, sheep and pigs by microinjection.

Nature - 1 Jan 2000

Hammer R E, Pursel V G, Rexroad C E, Wall R J, Bolt D J, Ebert K M, Palmiter R D, Brinster R L

Abstract excerpt

Direct microinjection has been used to introduce foreign DNA into a number of terminally differentiated cell types as well as embryos of several species including sea urchin, Candida elegans, Xenopus, Drosophila and mice. Various genes have been successfully introduced into mice including constructs consisting of the mouse metallothionein-I (MT) promoter/regulator region fused to either the rat or human growth...

Topics

Animals
Gene Expression Regulation
Genetic Techniques
Growth Hormone
Humans
Metallothionein
Microinjections
Mutation
Promoter Regions, Genetic
Rabbits
Sheep
Swine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 3892305
DOI: 10.1038/315680a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3892305-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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