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Article

Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.

The Journal of biological chemistry - 12 May 2000

Li C, Furge K A, Cheng Q C, Albright C F

Abstract excerpt

Cytokinesis and septation in the fission yeast Schizosaccharomyces pombe are studied as a model for mammalian cell division. In fission yeast, septation is positively regulated by Spg1, a Ras family GTPase that localizes to spindle-pole bodies (SPBs) throughout the cell cycle. As cells enter mitosis, Spg1 accumulates in an active, GTP-bound form and binds the Cdc7 protein kinase to cause Cdc7 translocation to...

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Identifiers

PMID: 10799520
DOI: 10.1074/jbc.275.19.14381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.PMID 10799520Read ↗

Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast.Semantic proximity Read ↗

Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16.Semantic proximity Read ↗

Identification of functional domains within the septation initiation network kinase, Cdc7.Semantic proximity Read ↗

Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.Semantic proximity Read ↗

Byr4, a dosage-dependent regulator of cytokinesis in S. pombe, interacts with a possible small GTPase pathway including Spg1 and Cdc16.Semantic proximity Read ↗

Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.Semantic proximity Read ↗

Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.Semantic proximity Read ↗

The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

Isolation and characterization of new fission yeast cytokinesis mutants.Semantic proximity Read ↗

Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.Semantic proximity Read ↗

Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

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