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Establishment and evaluation of a qPCR method for the detection of pfmdr1 mutations in Plasmodium falciparum, the causal agent of fatal malaria.

Diagnostic microbiology and infectious disease - 1 Sept 2024

Zhu Huiyin, Zhu Daiqian, Wu Kai, He Wei, Li Liugen, Li Tongfei, Liu Long, Liu Zhixin, Song Xiaonan, Cheng Weijia, Mo Jinyu, Yao Yi, Li Jian

Abstract excerpt

Drug resistance surveillance is a major integral part of malaria control programs. Molecular methods play a pivotal role in drug resistance detection and related molecular research. This study aimed to develop a rapid and accurate detection method for drug resistance of Plasmodium falciparum (P. falciparum). A quantitative real-time PCR (qPCR) assay has been developed that identifies the mutation at locus A256T...

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PMID: 38909426
DOI: 10.1016/j.diagmicrobio.2024.116400

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