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Article

Expansion of tumor-infiltrating lymphocytes in non-small cell lung cancer: Clinical potential and efficacy in EGFR mutation subsets.

Clinical immunology (Orlando, Fla.) - 1 Aug 2024

Lee Hyun, Lee Miseon, Lim Chae Lyul, Park Hye Seon, Song In Hye, Jeong Byung-Kwan, Kim Dong Kwan, Kim Yong-Hee, Choi Sehoon, Lee Geun Dong, Lee Sae Byul, Jung SungWook, Gong Gyungyub, Kim Sung-Bae, Yoo Changhoon, Kim Joo Young, Lee Hee Jin

Abstract excerpt

Our study aimed to expand tumor-infiltrating lymphocytes (TILs) from primary non-small cell lung cancers (NSCLCs) and evaluate their reactivity against tumor cells. We expanded TILs from 103 primary NSCLCs using histopathological analysis, flow cytometry, IFN-γ release assays, cell-mediated cytotoxicity assays, and in vivo efficacy tests. TIL expansion was observed in all cases, regardless of EGFR mutation...

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Identifiers

PMID: 38908769
DOI: 10.1016/j.clim.2024.110289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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