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Article

Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study.

Frontiers in immunology - 1 Jan 2024

Wu Pu, Xie Sinan, Cai Yunshi, Liu Hu, Lv Yinghao, Yang Ying, He Yucheng, Yin Bangjie, Lan Tian, Wu Hong

Abstract excerpt

Background: Observational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However, the causal relationship between peripheral blood immune cells and PSC remains insufficiently understood. Methods: A bidirectional two-sample Mendelian randomization (MR) analysis was implemented to determine the causal effect between PBC...

Topics

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Cholangitis, Sclerosing
Dendritic Cells
Genetic Predisposition to Disease
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Regulatory

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Open in PubMed Open full text

Identifiers

PMID: 39011035
DOI: 10.3389/fimmu.2024.1395513
PMCID: PMC11246896

Genes

CD28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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