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Article

Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into Macrophages.

International journal of molecular sciences - 1 Jun 2024

Grigor'eva Elena V, Karapetyan Lana V, Malakhova Anastasia A, Medvedev Sergey P, Minina Julia M, Hayrapetyan Varduhi H, Vardanyan Valentina S, Zakian Suren M, Arakelyan Arsen, Zakharyan Roksana

Abstract excerpt

Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein. Despite the existing data on MEFV mutations, the exact mechanism of their effect on the development of the pathological processes leading to the spontaneous and recurrent autoinflammatory attacks observed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38892289
DOI: 10.3390/ijms25116102
PMCID: PMC11173119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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