Article
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.
Neurobiology of disease - 1 Oct 2015
Fujisawa Takao, Yamaguchi Namiko, Kadowaki Hisae, Tsukamoto Yuka, Tsuburaya Naomi, Tsubota Atsushi, Takahashi Hiromitsu, Naguro Isao, Takahashi Yuji, Goto Jun, Tsuji Shoji, Nishitoh Hideki, Homma Kengo, Ichijo Hidenori
Abstract excerpt
Mutations in the Cu, Zn superoxide dismutase (SOD1) gene are one of the causative agents of amyotrophic lateral sclerosis (ALS). Although more than 100 different mutations in SOD1 have been identified, it is unclear whether all the mutations are pathogenic or just single nucleotide polymorphisms (SNPs) unrelated to the disease. Our previous systematic analysis found that all pathogenic SOD1 mutants (SOD1(mut))...
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