Article
Does the presence of AGG interruptions within the CGG repeat tract have a protective effect on the fertility phenotype of female FMR1 premutation carriers?
Journal of assisted reproduction and genetics - 1 Apr 2020
Friedman-Gohas M, Kirshenbaum M, Michaeli A, Domniz N, Elizur S, Raanani H, Orvieto R, Cohen Y
Abstract excerpt
PURPOSE: While FMR1 premutation carriers (CGG 55-200) were shown to have reduced success with IVF treatment (lower oocyte yield), studies reporting on the association between the number of CGG repeats and patients' response to controlled ovarian hyperstimulation (COH) are inconsistent. In the present study, we aim to explore whether the number of CGG repeats in women with premutation in FMR1 gene, undergoing COH...
Topics
- Adult
- Alleles
- Female
- Fertility
- Fertilization in Vitro
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Gonadotropins
- Heterozygote
- Humans
- Ovary
- Trinucleotide Repeat Expansion
- Trinucleotide Repeats