FMR1 premutation: not only important in premature ovarian failure but also in diminished ovarian reserve.

doi:10.1080/14647273.2016.1255356

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Article

FMR1 premutation: not only important in premature ovarian failure but also in diminished ovarian reserve.

Human fertility (Cambridge, England) - 1 Jun 2017

Eslami Ali, Farahmand Kamelia, Totonchi Mehdi, Madani Tahereh, Asadpour Ummulbanin, Zari Moradi Shabnam, Gourabi Hamid, Mohseni-Meybodi Anahita

Abstract excerpt

It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but their role in diminished ovarian reserve (DOR) is not clearly established. Moreover, the impact of smaller repeats at the boundary of premutation and normal is less clear. Therefore, we have compared the frequency of these intermediate (45-54 repeats) and premutation (>55) sized FMR1 CGG repeats among a...

Topics

Adult
DNA
Female
Fragile X Mental Retardation Protein
Genetic Predisposition to Disease
Humans
Infertility, Female
Ovarian Reserve
Primary Ovarian Insufficiency

Source

Open in PubMed

Identifiers

PMID: 27876427
DOI: 10.1080/14647273.2016.1255356

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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