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Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip

16 Jun 2024

Abstract excerpt

BACKGROUND: This study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral blood mononuclear cell (PBMC) and synovial tissues of animal hip osteoarthritis (OA) models. METHODS: Animals were assigned to the control (no treatment), sham (25 µL of sterile saline), and OA (25 µL of sterile saline and 2 mg of monoiodoacetate) groups....

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PMID: 38880910
DOI: 10.1186/s13018-024-04847-0

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