CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention.

doi:10.1161/JAHA.123.033791

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Article

CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention.

Journal of the American Heart Association - 18 Jun 2024

Tunehag Kayla R, Thomas Cameron D, Franchi Francesco, Rossi Joseph S, Keeley Ellen C, Anderson R David, Beitelshees Amber L, Duarte Julio D, Gong Yan, Kerensky Richard A, McDonough Caitrin W, Nguyen Anh B, Ortega-Paz Luis, Venkatesh Sanjay, Wang Yehua, Johnson Julie A, Winterstein Almut G, Stouffer George A, Angiolillo Dominick J, Cavallari Larisa H, Lee Craig R

Abstract excerpt

BACKGROUND: Cytochrome P450 2C19 (CYP2C19) intermediate and poor metabolizer patients exhibit diminished clopidogrel clinical effectiveness after percutaneous coronary intervention (PCI). However, outcome studies to date have lacked racial diversity. Thus, the impact of CYP2C19 genotype on cardiovascular outcomes in patients treated with clopidogrel who identify as Black or African American remains unclear....

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Identifiers

PMID: 38874073
DOI: 10.1161/JAHA.123.033791
PMCID: PMC11255757

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CYP2C19

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