Article
Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.
Circulation. Cardiovascular genetics - 1 Jun 2014
Cresci Sharon, Depta Jeremiah P, Lenzini Petra A, Li Allie Y, Lanfear David E, Province Michael A, Spertus John A, Bach Richard G
Abstract excerpt
BACKGROUND: Clopidogrel is recommended after acute myocardial infarction but has variable efficacy and safety, in part related to the effect of cytochrome P450 (CYP) polymorphisms on its metabolism. The effect of CYP polymorphisms on cardiovascular events among clopidogrel-treated patients after acute myocardial infarction remains controversial, and no studies to date have investigated the association of CYP...
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