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Article

Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks.

Nature genetics - 1 Jul 2024

McCaw Zachary R, Gao Jianhui, Lin Xihong, Gronsbell Jessica

Abstract excerpt

Within population biobanks, incomplete measurement of certain traits limits the power for genetic discovery. Machine learning is increasingly used to impute the missing values from the available data. However, performing genome-wide association studies (GWAS) on imputed traits can introduce spurious associations, identifying genetic variants that are not associated with the original trait. Here we introduce a new...

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PMID: 38872030
DOI: 10.1038/s41588-024-01793-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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