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Article

DOT1L maintains NK cell phenotype and function for optimal tumor control.

Cell reports - 25 Jun 2024

Sudholz Harrison, Schuster Iona S, Foroutan Momeneh, Sng Xavier, Andoniou Christopher E, Doan Anh, Camilleri Tania, Shen Zihan, Zaph Colby, Degli-Esposti Mariapia A, Huntington Nicholas D, Scheer Sebastian

Abstract excerpt

Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor microenvironment (TME) remains largely unknown. We demonstrate that the HMT DOT1L limits NK cell conversion to CD49a+ CD49b+ intILC1, a subset that can be observed in the TME in response to stimulation with transforming growth factor (TGF)-β and is correlated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38865244
DOI: 10.1016/j.celrep.2024.114333

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