Article
Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2021
Moreno-Nieves Uriel Y, Tay Joshua K, Saumyaa Saumyaa, Horowitz Nina B, Shin June Ho, Mohammad Imran A, Luca Bogdan, Mundy David C, Gulati Gunsagar S, Bedi Nikita, Chang Serena, Chen Chen, Kaplan Michael J, Rosenthal Eben L, Holsinger F Christopher, Divi Vasu, Baik Fred M, Sirjani Davud B, Gentles Andrew J, Newman Aaron M, Freud Aharon G, Sunwoo John B
Abstract excerpt
Natural killer (NK) cells comprise one subset of the innate lymphoid cell (ILC) family. Despite reported antitumor functions of NK cells, their tangible contribution to tumor control in humans remains controversial. This is due to incomplete understanding of the NK cell states within the tumor microenvironment (TME). Here, we demonstrate that peripheral circulating NK cells differentiate down two divergent...
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