Article
A Two-color Single-molecule Sequencing Platform and Its Clinical Applications.
Genomics, proteomics & bioinformatics - 9 May 2024
Chen Fang, Liu Bin, Chen Meirong, Jiang Zefei, Zhou Zhiliang, Wu Ping, Zhang Meng, Jin Huan, Li Linsen, Lu Liuyan, Shang Huan, Liu Lei, Chen Weiyue, Xu Jianfeng, Sun Ruitao, Wang Guangming, Zheng Jiao, Qi Jifang, Yang Bo, Zeng Lidong, Li Yan, Lv Hui, Zhao Nannan, Wang Wen, Cai Jinsen, Liu Yongfeng, Luo Weiwei, Zhang Juan, Zhang Yanhua, Fan Jicai, Dan Haitao, He Xuesen, Huang Wei, Sun Lei, Yan Qin
Abstract excerpt
DNA sequencers have become increasingly important research and diagnostic tools over the past 20 years. In this study, we developed a single-molecule desktop sequencer, GenoCare 1600 (GenoCare), which utilizes amplification-free library preparation and two-color sequencing-by-synthesis chemistry, making it more user-friendly compared with previous single-molecule sequencing platforms for clinical use. Using the...
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