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Effects of highly active antiretroviral therapy initiation on epigenomic DNA methylation in persons living with HIV

24 May 2024

Abstract excerpt

Introduction: Highly active antiretroviral therapy (HAART) helps improve some measures of accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the epigenome is not fully understood. Methods: In this study, we analyzed the DNA methylation profiles of PLWH ( n = 187) shortly before and approximately 2–3 years after they started HAART, as well as matched seronegative (SN)...

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PMID: 38855142
DOI: 10.3389/fbinf.2024.1357889

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