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Article

Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns

11 Jan 2023

Abstract excerpt

BACKGROUND: Previous epigenome-wide association studies have shown that HIV infection can disrupt the host DNA methylation landscape. However, it remains unclear how antiretroviral therapy (ART) affects the HIV-induced epigenetic modifications. METHODS: 184 individuals with HIV from the NEAT001/ANRS143 clinical trial (with pre-ART and post-ART samples [96 weeks of follow-up]) and 44 age-and-sex matched...

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PMID: 36640455
DOI: 10.1016/j.ebiom.2022.104434

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