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Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy

13 Sept 2019

Abstract excerpt

Abstract Background Persistence of latent, replication-competent provirus in CD4+T cells of human immunodeficiency virus (HIV)-infected individuals on antiretroviral treatment (ART) is the main obstacle for virus eradication. Methylation of the proviral 5′ long terminal repeat (LTR) promoter region has been proposed as a possible mechanism contributing to HIV latency; however, conflicting observations exist...

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PMID: 31519219
DOI: 10.1186/s13148-019-0735-9

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