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Article

Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color.

Nature communications - 7 Jun 2024

Kim Beomsu, Kim Dan Say, Shin Joong-Gon, Leem Sangseob, Cho Minyoung, Kim Hanji, Gu Ki-Nam, Seo Jung Yeon, You Seung Won, Martin Alicia R, Park Sun Gyoo, Kim Yunkwan, Jeong Choongwon, Kang Nae Gyu, Won Hong-Hee

Abstract excerpt

Evidence for adaptation of human skin color to regional ultraviolet radiation suggests shared and distinct genetic variants across populations. However, skin color evolution and genetics in East Asians are understudied. We quantified skin color in 48,433 East Asians using image analysis and identified associated genetic variants and potential causal genes for skin color as well as their polygenic interplay with...

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Share to Adaptation, Physiological
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to East Asian People

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Quantitative Trait Loci

Share to Skin Pigmentation

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Source

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Identifiers

PMID: 38849341
DOI: 10.1038/s41467-024-49031-4
PMCID: PMC11161515

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